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Article

Genetic alterations in the 3q26.31-32 locus confer an aggressive prostate cancer phenotype.

Communications biology - 14 Aug 2020

Simpson Benjamin S, Camacho Niedzica, Luxton Hayley J, Pye Hayley, Finn Ron, Heavey Susan, Pitt Jason, Moore Caroline M, Whitaker Hayley C

Abstract excerpt

Large-scale genetic aberrations that underpin prostate cancer development and progression, such as copy-number alterations (CNAs), have been described but the consequences of specific changes in many identified loci is limited. Germline SNPs in the 3q26.31 locus are associated with aggressive prostate cancer, and is the location of NAALADL2, a gene overexpressed in aggressive disease. The closest gene to NAALADL2...

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Share to Chromosomes, Human, Pair 3
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 32796921
DOI: 10.1038/s42003-020-01175-x
PMCID: PMC7429505

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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