Article
Phosphorylation status of epidermal growth factor receptor is closely associated with responsiveness to gefitinib in pulmonary adenocarcinoma.
Human pathology - 1 Mar 2008
Hijiya Naoki, Miyawaki Michiyo, Kawahara Katsunobu, Akamine Shinji, Tsuji Koh-Ichi, Kadota Jun-Ichi, Akizuki Shin'ichiro, Uchida Tomohisa, Matsuura Keiko, Tsukamoto Yoshiyuki, Moriyama Masatsugu
Abstract excerpt
Twenty-one cases of primary lung carcinoma were analyzed for correlations between the presence of somatic mutations of the epidermal growth factor receptor (EGFR) gene and the phosphorylation status of EGFR, which was analyzed by immunohistochemistry with antibodies recognizing the phosphorylated form of EGFR. Somatic mutations were detected in 11 (52.4%) of the 21 cases. Immunohistochemistry with an antibody...
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