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Article

Apolipoprotein E epsilon4 genotype as a risk factor for cognitive decline and dementia: data from the Canadian Study of Health and Aging.

CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne - 12 Oct 2004

Hsiung Ging-Yuek R, Sadovnick A Dessa, Feldman Howard

Abstract excerpt

BACKGROUND: Apolipoprotein E (ApoE) epsilon4 genotype is a well-established risk factor for Alzheimer's disease (AD). However, its effect on predicting conversion from normal to "cognitive impairment, no dementia" (CIND) and from CIND to AD is less clear. METHODS: We used a nested case-control design from the population-based Canadian Study of Health and Aging (CSHA) to examine the effect of ApoE epsilon4...

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Identifiers

PMID: 15477624
DOI: 10.1503/cmaj.1031789
PMCID: PMC522651

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