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Article

Histone deacetylase 4 inhibition ameliorates the social deficits induced by Ephrin-B2 mutation.

Progress in neuro-psychopharmacology & biological psychiatry - 10 Jan 2023

Ju Peijun, Chen Jianhua, Ma Le, Cheng Ying, Liu Jiwei, Sun Ying, Zhu Cuizhen, Shen Zhe, Wang Wei, Peng Yanmin, Ali Usman, Xu Nanjie, Chen Jinghong

Abstract excerpt

Deterioration of inhibitory synapse may be an essential neurological basis underlying abnormal social behaviours. Manipulations that regulate GABAergic transmission are associated with improved behavioural phenotypes in sociability. The synaptic protein, Ephrin-B2 (EB2), plays an important role in the maintenance and reconfiguration of inhibitory synapses in the medial prefrontal cortex (mPFC). However, the...

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PMID: 36029930
DOI: 10.1016/j.pnpbp.2022.110622

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