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Article

Developing a Sensitive Platform to Measure 5-Methyltetrahydrofolate in Subjects with MTHFR and PON1 Gene Polymorphisms.

Nutrients - 13 Aug 2022

Lu Mong-Liang, Ku Wei-Chi, Syifa Nailis, Hu Shu-Chin, Chou Chia-Te, Wu Yi-Hsio, Kuo Po-Hsiu, Chen Chun-Hsin, Chen Wei J, Wu Tzu-Hua

Abstract excerpt

Inadequate levels of 5-methyltetrahydrofolate (5-MTHF) and the T variant of MTHFR C677T have been suggested to be associated with an increased risk of developing mental illness, whereas the PON1 SNP variant provides a protective role. However, reports validating the methodology for plasma 5-MTHF levels in schizophrenia patients are limited. A sensitive LC−MS/MS system using an amide column and calibration curve...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 36014826
DOI: 10.3390/nu14163320
PMCID: PMC9412631

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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