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Article

Targeted massively parallel sequencing of a panel of putative breast cancer susceptibility genes in a large cohort of multiple-case breast and ovarian cancer families.

Journal of medical genetics - 1 Jan 2016

Li Jun, Meeks Huong, Feng Bing-Jian, Healey Sue, Thorne Heather, Makunin Igor, Ellis Jonathan, Campbell Ian, Southey Melissa, Mitchell Gillian, Clouston David, Kirk Judy, Goldgar David, Chenevix-Trench Georgia

Abstract excerpt

INTRODUCTION: Gene panel testing for breast cancer susceptibility has become relatively cheap and accessible. However, the breast cancer risks associated with mutations in many genes included in these panels are unknown. METHODS: We performed custom-designed targeted sequencing covering the coding exons of 17 known and putative breast cancer susceptibility genes in 660 non-BRCA1/2 women with familial breast...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26534844
DOI: 10.1136/jmedgenet-2015-103452
PMCID: PMC4915734

Genes

ATM
CDH1
CHEK2
PALB2
BARD1
BRCA1
BRIP1
CDK4
MRE11
NBN
PTEN
RAD50
STK11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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