Article
MTHFR SNPs (Methyl Tetrahydrofolate Reductase, Single Nucleotide Polymorphisms) C677T and A1298C Prevalence and Serum Homocysteine Levels in >2100 Hypofertile Caucasian Male Patients
Biomolecules - 7 Aug 2022
Clément Arthur, Amar Edouard, Brami Charles, Clément Patrice, Alvarez Silvia, Jacquesson-Fournols Laetitia, Davy Céline, Lalau-Keraly Marc, Menezo Yves
Abstract excerpt
Methylation is a crucially important ubiquitous biochemical process, which covalently adds methyl groups to a variety of molecular targets. It is the key regulatory process that determines the acquisition of imprinting and epigenetic marks during gametogenesis. Methylation processes are dependent upon two metabolic cycles, the folates and the one-carbon cycles. The activity of these two cycles is compromised by...
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