Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Significant impact of the MTHFR polymorphisms and haplotypes on male infertility risk.

PloS one - 1 Jan 2013

Gupta Nishi, Sarkar Saumya, David Archana, Gangwar Pravin Kumar, Gupta Richa, Khanna Gita, Sankhwar Satya Narayan, Khanna Anil, Rajender Singh

Abstract excerpt

BACKGROUND: Methylenetetrahydrofolate reductase (MTHFR) converts 5,10-methylene tetrahydrofolate to 5-methyl tetrahydrofolate and affects the activity of cellular cycles participating in nucleotide synthesis, DNA repair, genome stability, maintenance of methyl pool, and gene regulation. Genetically compromised MTHFR activity has been suggested to affect male fertility. The objective of the present study was to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Case-Control Studies
Share to Haplotypes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Infertility, Male

Share to Linkage Disequilibrium

Share to Methylenetetrahydrofolate Reductase (NADPH2)

Share to Odds Ratio

Share to Polymorphism, Restriction Fragment Length

Share to Sequence Analysis, DNA

Source

Open in PubMed Open full text

Identifiers

PMID: 23874907
DOI: 10.1371/journal.pone.0069180
PMCID: PMC3715460

Genes

MTHFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Significant impact of the MTHFR polymorphisms and haplotypes on male infertility risk.PMID 23874907Read ↗

Association of the MTHFR 677C>T and 1298A>C polymorphisms and male infertility risk: a meta-analysis.Semantic proximity Read ↗

Methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and male infertility risk: An updated meta-analysis.Semantic proximity Read ↗

Relationship between genetic polymorphisms of methylenetetrahydrofolate reductase (C677T, A1298C, and G1793A) as risk factors for idiopathic male infertility.Semantic proximity Read ↗

Association between MTHFR A1298C polymorphism and male infertility: A meta-analysis.Semantic proximity Read ↗

Associations of C677T polymorphism in methylenetetrahydrofolate reductase (MTHFR) gene with male infertility risk: A meta-analysis.Semantic proximity Read ↗

MTHFR C677T、MTHFR A1298C、MTRR A66G and MTR A2756G polymorphisms and male infertility risk: a systematic review and meta-analysis.Semantic proximity Read ↗

Association of C677T transition of the human methylenetetrahydrofolate reductase (MTHFR) gene with male infertility.Semantic proximity Read ↗

Association of the Methylenetetrahydrofolate Reductase Gene A1298C Polymorphism with Male Infertility: A Meta‐AnalysisSemantic proximity Read ↗

MTHFR A1298C polymorphism and idiopathic male infertility.Semantic proximity Read ↗

Association between C677T and A1298C polymorphisms of the MTHFR gene and risk of male infertility: a meta-analysis.Semantic proximity Read ↗

MTHFR 677C>T and 1298A>C polymorphisms and male infertility risk: a meta-analysis.Semantic proximity Read ↗

Human MTHFR-G1793A transition may be a protective mutation against male infertility: a genetic association study and in silico analysis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.