MTHFR (methylenetetrahydrofolate reductase: EC 1.5.1.20) SNPs (single-nucleotide polymorphisms) and homocysteine in patients referred for investigation of fertility.

doi:10.1007/s10815-021-02200-6

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

MTHFR (methylenetetrahydrofolate reductase: EC 1.5.1.20) SNPs (single-nucleotide polymorphisms) and homocysteine in patients referred for investigation of fertility.

Journal of assisted reproduction and genetics - 1 Sept 2021

Ménézo Yves, Patrizio Pasquale, Alvarez Silvia, Amar Edouard, Brack Michel, Brami Charles, Chouteau Jacques, Clement Arthur, Clement Patrice, Cohen Marc, Cornet Dominique, Dale Brian, D' Amato Guiseppe, Jacquesson-Fournols Laetitia, Mares Pierre, Neveux Paul, Sage Jean Clement, Servy Edouard, Huong To Minh, Viot Geraldine

Abstract excerpt

PURPOSE: MTHFR, one of the major enzymes in the folate cycle, is known to acquire single-nucleotide polymorphisms that significantly reduce its activity, resulting in an increase in circulating homocysteine. Methylation processes are of crucial importance in gametogenesis, involved in the regulation of imprinting and epigenetic tags on DNA and histones. We have retrospectively assessed the prevalence of MTHFR...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Abortion, Spontaneous

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to France

Share to Heterozygote

Share to Homocysteine

Share to Homozygote

Share to Infertility

Share to Methylenetetrahydrofolate Reductase (NADPH2)

Share to Polymorphism, Single Nucleotide

Source

Open in PubMed Open full text

Identifiers

PMID: 33914208
DOI: 10.1007/s10815-021-02200-6
PMCID: PMC8490548

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

MTHFR (methylenetetrahydrofolate reductase: EC 1.5.1.20) SNPs (single-nucleotide polymorphisms) and homocysteine in patients referred for investigation of fertility.PMID 33914208Read ↗

MTHFR SNPs (Methyl Tetrahydrofolate Reductase, Single Nucleotide Polymorphisms) C677T and A1298C Prevalence and Serum Homocysteine Levels in >2100 Hypofertile Caucasian Male PatientsSemantic proximity Read ↗

[Importance of the determination of MTHFR SNPs (Methylene Tetrahydrofolate Reductase Single Nucleotide Polymorphisms) in couple infertility].Semantic proximity Read ↗

Significant impact of the MTHFR polymorphisms and haplotypes on male infertility risk.Semantic proximity Read ↗

Impact of 677C>T mutation of the 5,10-methylenetetrahydrofolate reductase on IVF outcome: is screening necessary for all infertile women?Semantic proximity Read ↗

MTHFR A1298C polymorphism and idiopathic male infertility.Semantic proximity Read ↗

Polymorphisms in MTHFR and MTRR genes associated with blood plasma homocysteine concentration and sperm counts.Semantic proximity Read ↗

The Fertility Effects of the C677T Mutation in the Methylenetetrahydrofolate Reductase Gene: A Cross-Site Systematic Review and Meta-Analysis.Semantic proximity Read ↗

T677T Methylenetetrahydrofolate Reductase Single Nucleotide Polymorphisms Increased Prevalence in a Subgroup of Infertile Patients with Endometriosis.Semantic proximity Read ↗

Methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and male infertility risk: An updated meta-analysis.Semantic proximity Read ↗

MTHFR polymorphisms C677T and A1298C and associations with IVF outcomes in Brazilian women.Semantic proximity Read ↗

Presence of MTHFR Polymorphisms and the Levels of Folic Acid and Homocysteine in Women Enrolled in an Assisted Reproductive ProgramSemantic proximity Read ↗

Role of 677C→T polymorphism a single substitution in methylenetetrahydrofolate reductase (MTHFR) gene in North Indian infertile men.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.