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Article

Association of C677T transition of the human methylenetetrahydrofolate reductase (MTHFR) gene with male infertility.

Reproduction, fertility, and development - 1 Apr 2016

Karimian Mohammad, Colagar Abasalt Hosseinzadeh

Abstract excerpt

The human methylenetetrahydrofolate reductase (MTHFR) gene encodes one of the key enzymes in folate metabolism. This gene is located on chromosome 1 (1p36.3), which has 12 exons. The aim of the present study was to investigate the possible association of the two (C677T and A1298C) polymorphisms of this gene with male infertility. In a case-control study, 250 blood samples were collected from IVF centres in Sari...

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Source

Identifiers

PMID: 25412139
DOI: 10.1071/RD14186

Genes

MTHFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Association of C677T transition of the human methylenetetrahydrofolate reductase (MTHFR) gene with male infertility.PMID 25412139Read ↗

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Association between MTHFR A1298C polymorphism and male infertility: A meta-analysis.Semantic proximity Read ↗

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Association between C677T and A1298C polymorphisms of the MTHFR gene and risk of male infertility: a meta-analysis.Semantic proximity Read ↗

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