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Article

MTHFR A1298C polymorphism and idiopathic male infertility.

Journal of postgraduate medicine - 1 Jan 2000

Singh K, Singh S K, Raman R

Abstract excerpt

BACKGROUND: DNA methylation is an important epigenetic feature of DNA that plays a pivotal role in gene expression regulation during spermatogenesis. The enzyme methylenetetrahydrofolate reductase (MTHFR) catalyses the formation of folate intermediates that are vital for DNA synthesis and methylation reactions. C677T and A1298C variants of MTHFR result in reduced plasma folate and increase the susceptibility to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 20935396
DOI: 10.4103/0022-3859.70935

Genes

MTHFR

Variants

Provenance

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MTHFR A1298C polymorphism and idiopathic male infertility.PMID 20935396Read ↗

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Significant impact of the MTHFR polymorphisms and haplotypes on male infertility risk.Semantic proximity Read ↗

Association between MTHFR A1298C polymorphism and male infertility: A meta-analysis.Semantic proximity Read ↗

Association of the Methylenetetrahydrofolate Reductase Gene A1298C Polymorphism with Male Infertility: A Meta‐AnalysisSemantic proximity Read ↗

Association of the MTHFR 677C>T and 1298A>C polymorphisms and male infertility risk: a meta-analysis.Semantic proximity Read ↗

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Methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and male infertility risk: An updated meta-analysis.Semantic proximity Read ↗

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