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Article

[Importance of the determination of MTHFR SNPs (Methylene Tetrahydrofolate Reductase Single Nucleotide Polymorphisms) in couple infertility].

Gynecologie, obstetrique, fertilite & senologie - 1 May 2020

Clément A, Chouteau J, Clément P, Ménézo Y

Abstract excerpt

OBJECTIVE: MTHFR SNPs (Methylene Tetrahydrofolate reductase Single Nucleotide polymorphisms) are biochemical modifications decreasing the capacity to form 5 MTHF 5 methyltetrahydrofolate (5MTHF). Their presence reduces the capacity of the One Carbon cycle, and so the regeneration of Homocysteine (Hcy) and in fine strongly perturbs all the methylation processes. As methylation processes are major regulators in...

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PMID: 32145452
DOI: 10.1016/j.gofs.2020.02.015

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