Associations of C677T polymorphism in methylenetetrahydrofolate reductase (MTHFR) gene with male infertility risk: A meta-analysis.

doi:10.1016/j.ejogrb.2017.03.004

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Article

Associations of C677T polymorphism in methylenetetrahydrofolate reductase (MTHFR) gene with male infertility risk: A meta-analysis.

European journal of obstetrics, gynecology, and reproductive biology - 1 May 2017

Hong Hui-Hui, Hu Yan, Yu Xiao-Qing, Zhou Liang, Lv Mo-Qi, Sun Ying, Ren Wen-Juan, Zhou Dang-Xia

Abstract excerpt

PURPOSE: Methylenetetrahydrofolate reductase is one of the key enzymes in folate metabolism. But the association between polymorphism and the risk of male infertility is still controversial. Therefore, this study used a meta-analysis on the collection of data to analyze MTHFR gene C677T polymorph...

Topics

Alleles
Case-Control Studies
Folic Acid
Humans
Infertility, Male
Male
Methylenetetrahydrofolate Reductase (NADPH2)
Polymorphism, Single Nucleotide
Risk Factors

Source

Open in PubMed

Identifiers

PMID: 28363185
DOI: 10.1016/j.ejogrb.2017.03.004

Genes

MTHFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-28363185-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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