Article
Structures of the Omicron spike trimer with ACE2 and an anti-Omicron antibody.
Science (New York, N.Y.) - 4 Mar 2022
Yin Wanchao, Xu Youwei, Xu Peiyu, Cao Xiaodan, Wu Canrong, Gu Chunyin, He Xinheng, Wang Xiaoxi, Huang Sijie, Yuan Qingning, Wu Kai, Hu Wen, Huang Zifu, Liu Jia, Wang Zongda, Jia Fangfang, Xia Kaiwen, Liu Peipei, Wang Xueping, Song Bin, Zheng Jie, Jiang Hualiang, Cheng Xi, Jiang Yi, Deng Su-Jun, Xu H Eric
Abstract excerpt
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant has become the dominant infective strain. We report the structures of the Omicron spike trimer on its own and in complex with angiotensin-converting enzyme 2 (ACE2) or an anti-Omicron antibody. Most Omicron mutations are located on the surface of the spike protein and change binding epitopes to many current antibodies. In the...
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