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Article

The emerging role of furin in neurodegenerative and neuropsychiatric diseases

23 Aug 2022

Abstract excerpt

Furin is an important mammalian proprotein convertase that catalyzes the proteolytic maturation of a variety of prohormones and proproteins in the secretory pathway. In the brain, the substrates of furin include the proproteins of growth factors, receptors and enzymes. Emerging evidence, such as reduced FURIN mRNA expression in the brains of Alzheimer's disease patients or schizophrenia patients, has implicated a...

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PMID: 35996194
DOI: 10.1186/s40035-022-00313-1

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