DDX58 Is Associated With Susceptibility to Severe Influenza Virus Infection in Children and Adolescents.

doi:10.1093/infdis/jiac350

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

DDX58 Is Associated With Susceptibility to Severe Influenza Virus Infection in Children and Adolescents.

The Journal of infectious diseases - 28 Nov 2022

Lee Sanghun, Zhang Yu, Newhams Margaret, Novak Tanya, Thomas Paul G, Mourani Peter M, Hall Mark W, Loftis Laura L, Cvijanovich Natalie Z, Tarquinio Keiko M, Schwarz Adam J, Weiss Scott L, Thomas Neal J, Markovitz Barry, Cullimore Melissa L, Sanders Ronald C, Zinter Matt S, Sullivan Janice E, Halasa Natasha B, Bembea Melania M, Giuliano John S, Typpo Katri V, Nofziger Ryan A, Shein Steven L, Kong Michele, Coates Bria M, Weiss Scott T, Lange Christoph, Su Helen C, Randolph Adrienne G

Abstract excerpt

BACKGROUND: Seasonal influenza virus infection causes a range of disease severity, including lower respiratory tract infection with respiratory failure. We evaluated the association of common variants in interferon (IFN) regulatory genes with susceptibility to critical influenza infection in children. METHODS: We performed targeted sequencing of 69 influenza-associated candidate genes in 348 children from 24 US...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adolescent

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Child

Share to Communicable Diseases

Share to DEAD Box Protein 58

Share to Influenza, Human

Share to Interferons

Share to Polymorphism, Single Nucleotide

Share to Receptors, Immunologic

Source

Open in PubMed Open full text

Identifiers

PMID: 35986912
DOI: 10.1093/infdis/jiac350
PMCID: PMC10205622

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

DDX58 Is Associated With Susceptibility to Severe Influenza Virus Infection in Children and Adolescents.PMID 35986912Read ↗

Defective RNA sensing by RIG-I in severe influenza virus infectionSemantic proximity Read ↗

Transcriptomic profiles of multiple organ dysfunction syndrome phenotypes in pediatric critical influenza.Semantic proximity Read ↗

IFIH1 and DDX58 gene variants in pediatric rheumatic diseasesSemantic proximity Read ↗

Association of IFIH1 and DDX58 genes polymorphism with susceptibility to COVID-19.Semantic proximity Read ↗

Genetic associations with viral respiratory illnesses and asthma control in children.Semantic proximity Read ↗

Impact of IFITM3 rs12252 and IFNAR2 rs2236757 SNP polymorphisms on influenza virus infection outcomes in Moroccan patients.Semantic proximity Read ↗

DNA methylation and single-nucleotide polymorphisms in DDX58 are associated with hand, foot and mouth disease caused by enterovirus 71.Semantic proximity Read ↗

Severe viral respiratory infections in children with IFIH1 loss-of-function mutations.Semantic proximity Read ↗

A common polymorphism in the caspase recruitment domain of RIG-I modifies the innate immune response of human dendritic cells.Semantic proximity Read ↗

Recurrent respiratory viral diseases and chronic sequelae due to dominant negative IFIH1Semantic proximity Read ↗

Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes.Semantic proximity Read ↗

Genetic polymorphisms in host antiviral genes: associations with humoral and cellular immunity to measles vaccine.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.