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Article

Genetic polymorphisms in host antiviral genes: associations with humoral and cellular immunity to measles vaccine.

Vaccine - 8 Nov 2011

Haralambieva Iana H, Ovsyannikova Inna G, Umlauf Benjamin J, Vierkant Robert A, Shane Pankratz V, Jacobson Robert M, Poland Gregory A

Abstract excerpt

Host antiviral genes are important regulators of antiviral immunity and plausible genetic determinants of immune response heterogeneity after vaccination. We genotyped and analyzed 307 common candidate tagSNPs from 12 antiviral genes in a cohort of 745 schoolchildren immunized with two doses of measles-mumps-rubella (MMR) vaccine. Associations between SNPs/haplotypes and measles virus-specific immune outcomes...

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Identifiers

PMID: 21939710
DOI: 10.1016/j.vaccine.2011.09.043
PMCID: PMC3941984

Genes

OAS1
ADAR

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