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Article

A common polymorphism in the caspase recruitment domain of RIG-I modifies the innate immune response of human dendritic cells.

Journal of immunology (Baltimore, Md. : 1950) - 1 Jul 2010

Hu Jianzhong, Nistal-Villán Estanislao, Voho Anu, Ganee Arnold, Kumar Madhu, Ding Yaomei, García-Sastre Adolfo, Wetmur James G

Abstract excerpt

Infection of human dendritic cells (DCs) by negative-strand RNA viruses, such as Newcastle disease virus, leads to the induction of the IFNbeta gene, IFNB1, through the activation of the RNA helicase RIG-I, which is encoded by DDX58. Expression levels of IFNB1 and DDX58 in infected DCs showed pos...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20511549
DOI: 10.4049/jimmunol.0903291
PMCID: PMC2917324

Genes

IFNB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20511549-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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