Article
Transcriptomic profiles of multiple organ dysfunction syndrome phenotypes in pediatric critical influenza.
Frontiers in immunology - 1 Jan 2023
Novak Tanya, Crawford Jeremy Chase, Hahn Georg, Hall Mark W, Thair Simone A, Newhams Margaret M, Chou Janet, Mourani Peter M, Tarquinio Keiko M, Markovitz Barry, Loftis Laura L, Weiss Scott L, Higgerson Renee, Schwarz Adam J, Pinto Neethi P, Thomas Neal J, Gedeit Rainer G, Sanders Ronald C, Mahapatra Sidharth, Coates Bria M, Cvijanovich Natalie Z, Ackerman Kate G, Tellez David W, McQuillen Patrick, Kurachek Stephen C, Shein Steven L, Lange Christoph, Thomas Paul G, Randolph Adrienne G
Abstract excerpt
Background: Influenza virus is responsible for a large global burden of disease, especially in children. Multiple Organ Dysfunction Syndrome (MODS) is a life-threatening and fatal complication of severe influenza infection. Methods: We measured RNA expression of 469 biologically plausible candidate genes in children admitted to North American pediatric intensive care units with severe influenza virus infection...
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