Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Anti-HMGB1 neutralizing antibody ameliorates neutrophilic airway inflammation by suppressing dendritic cell-mediated Th17 polarization.

Mediators of inflammation - 1 Jan 2014

Zhang Fang, Huang Gang, Hu Bo, Fang Li-Ping, Cao E-Hong, Xin Xiao-Feng, Song Yong, Shi Yi

Abstract excerpt

We demonstrate that high mobility group box 1 protein (HMGB1) directs Th17 skewing by regulating dendritic cell (DC) function. First, our in vitro studies reveal that recombinant HMGB1 (rHMGB1) activates myeloid DCs to produce IL-23 in vitro, and rHMGB1-activated DCs prime naïve lymphocytes to produce the Th17 cytokine IL-17A. Second, we demonstrate that anti-HMGB1 neutralizing antibody attenuates HMGB1...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adoptive Transfer
Share to Antibodies, Neutralizing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Bronchoalveolar Lavage Fluid

Share to CD11c Antigen

Share to HMGB1 Protein

Share to Interleukin-23

Share to Ovalbumin

Share to Th17 Cells

Source

Open in PubMed Open full text

Identifiers

PMID: 24959003
DOI: 10.1155/2014/257930
PMCID: PMC4052055

Genes

HMGB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Anti-HMGB1 neutralizing antibody ameliorates neutrophilic airway inflammation by suppressing dendritic cell-mediated Th17 polarization.PMID 24959003Read ↗

MBD2 Regulates Th17 Cell Differentiation and Experimental Severe Asthma by Affecting IRF4 ExpressionSemantic proximity Read ↗

High-mobility group nucleosome-binding protein 1 acts as an alarmin and is critical for lipopolysaccharide-induced immune responses.Semantic proximity Read ↗

MBD2 regulates differentiation and function of Th17 cells in neutrophils- dominant asthma via HIF-1αSemantic proximity Read ↗

House dust mite-driven neutrophilic airway inflammation in mice with TNFAIP3-deficient myeloid cells is IL-17-independent.Semantic proximity Read ↗

Human iPSC-MSCs prevent steroid-resistant neutrophilic airway inflammation via modulating Th17 phenotypesSemantic proximity Read ↗

The HMGB1 (C106A) mutation inhibits IL-10-producing CD19hiFcγRIIbhi B cell expansion by suppressing STAT3 activation in mice.Semantic proximity Read ↗

Th17 responses in chronic allergic airway inflammation abrogate regulatory T-cell-mediated tolerance and contribute to airway remodeling.Semantic proximity Read ↗

Peptidoglycan recognition protein 1 enhances experimental asthma by promoting Th2 and Th17 and limiting regulatory T cell and plasmacytoid dendritic cell responses.Semantic proximity Read ↗

A novel subset of mouse NKT cells bearing the IL-17 receptor B responds to IL-25 and contributes to airway hyperreactivity.Semantic proximity Read ↗

Haemophilus influenzae infection drives IL-17-mediated neutrophilic allergic airways disease.Semantic proximity Read ↗

An inhaled dose of budesonide induces genes involved in transcription and signaling in the human airways: enhancement of anti‐ and proinflammatory effector genesSemantic proximity Read ↗

Epithelial reticulon 4B (Nogo-B) is an endogenous regulator of Th2-driven lung inflammationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.