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Article

High mobility group box-1 protein regulate immunosuppression of regulatory T cells through toll-like receptor 4.

Cytokine - 1 Jun 2011

Zhu Xiao-Mei, Yao Yong-Ming, Liang Hua-Ping, Xu Chang-Tao, Dong Ning, Yu Yan, Sheng Zhi-Yong

Abstract excerpt

INTRODUCTION: High mobility group box-1 protein (HMGB1), a recently recognized mediator of immune response might contribute to immune suppression when released extracellularly. The present study was performed to clarify effects of HMGB1 on regulatory T cells (Tregs) and the involvement of toll-like receptor (TLR) 4 signaling. METHODS: CD4(+)CD25(+)Tregs, isolated from spleens of normal mice and treated with HMGB1...

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Source

Identifiers

PMID: 21419643
DOI: 10.1016/j.cyto.2011.02.017

Genes

HMGB1
TLR4
CTLA4

Variants

Provenance

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