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Article

Cutaneous malignant melanoma and Parkinson disease: Common pathways?

Annals of neurology - 1 Dec 2016

Inzelberg Rivka, Flash Shira, Friedman Eitan, Azizi Esther

Abstract excerpt

The mechanisms underlying the high prevalence of cutaneous malignant melanoma (CMM) in Parkinson disease (PD) are unclear, but plausibly involve common pathways. 129Ser-phosphorylated α-synuclein, a pathological PD hallmark, is abundantly expressed in CMM, but not in normal skin. In inherited PD, PARK genes harbor germline mutations; the same genes are somatically mutated in CMM, or their encoded proteins are...

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PMID: 27761938
DOI: 10.1002/ana.24802

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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