Article
Characterization of genetic subclonal evolution in pancreatic cancer mouse models.
Nature communications - 28 Nov 2019
Niknafs Noushin, Zhong Yi, Moral John Alec, Zhang Lance, Shao Melody Xiaoshan, Lo April, Makohon-Moore Alvin, Iacobuzio-Donahue Christine A, Karchin Rachel
Abstract excerpt
The KPC mouse model, driven by the Kras and Trp53 transgenes, is well regarded for faithful recapitulation of human pancreatic cancer biology. However, the extent that this model recapitulates the subclonal evolution of this tumor type is unknown. Here we report evidence of continuing subclonal evolution after tumor initiation that largely reflect copy number alterations that target cellular processes of...
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