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Induced pluripotent stem cells display a distinct set of MHC I-associated peptides shared by human cancers

1 Aug 2022

Abstract excerpt

Previous reports showed that mouse vaccination with pluripotent stem cells (PSCs) induces durable anti-tumor immune responses via T cell recognition of some elusive oncofetal epitopes. We characterize the MHC I-associated peptide (MAP) repertoire of human induced PSCs (iPSCs) using proteogenomics. Our analyses reveal a set of 46 pluripotency-associated MAPs (paMAPs) absent from the transcriptome of normal tissues...

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PMID: 35977509
DOI: 10.1016/j.celrep.2022.111241

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