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Article

Antitumor effects of iPSC-based cancer vaccine in pancreatic cancer

6 May 2021

Abstract excerpt

Induced pluripotent stem cells (iPSCs) and cancer cells share cellular similarities and transcriptomic profiles. Here, we show that an iPSC-based cancer vaccine, comprised of autologous iPSCs and CpG, stimulated cytotoxic antitumor CD8 + T cell effector and memory responses, induced cancer-specific humoral immune responses, reduced immunosuppressive CD4 + T regulatory cells, and prevented tumor formation in 75%...

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PMID: 33961792
DOI: 10.1016/j.stemcr.2021.04.004

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