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Article

Natural immunity to pluripotency antigen OCT4 in humans

19 Apr 2010

Abstract excerpt

OCT4 is a transcription factor critical for the pluripotency of human embryonal stem (ES) and induced pluipotency stem (IPS) cells. OCT4 is commonly expressed in germ-cell tumors as well as putative cancer stem cells in several tumors, and is a key determinant of oncogenic fate in germ-cell tumors. The capacity of the human immune system to recognize this critical stem-cell gene is not known, but has implications...

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PMID: 20404147
DOI: 10.1073/pnas.0915086107

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