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Establishment of a human-induced pluripotent stem cell line from a long QT syndrome type 2 patient harboring a KCNH2 mutation.

Stem cell research - 1 Dec 2024

Mun Dasom, Kang Ji-Young, Park Malgeum, Yoo Gyeongseo, Kim Hyoeun, Yun Nuri, Mi Hwang You, Joung Boyoung

Abstract excerpt

Long QT syndrome type 2 (LQT2) is a heart disorder resulting from a loss-of-function mutation in theKCNH2gene that causes loss of Kv11.1 channel function, potentially resulting in syncope, arrhythmias, and sudden death. We derived induced pluripotent stem cell line from PBMC of LQT2 patient carrying a variant of pathogenic variant (c.157G > A; p.Gly53Ser). The generation of iPSC lines was achieved using the...

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Identifiers

PMID: 39454535
DOI: 10.1016/j.scr.2024.103592

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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Establishment of a human-induced pluripotent stem cell line from a long QT syndrome type 2 patient harboring a KCNH2 mutation.PMID 39454535Read ↗

Generation and characterization of an induced pluripotent stem cell (iPSC) line (NUIGi003-A) from a long QT syndrome type 2 (LQT2) patient harbouring the KCNH2 c.2464G>A pathogenic variant.Semantic proximity Read ↗

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Human induced pluripotent stem cell line ZZUNEUi027-A generated from a long QT syndrome patient with a heterozygous KCNH2 (c. 128 A > G) mutant.Semantic proximity Read ↗

Establishment of human embryonic stem cell WAe009-A-88 carrying a long QT syndrome mutation in KCNH2.Semantic proximity Read ↗

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Generation of human induced pluripotent stem cell line from a patient with a long QT syndrome type 2.Semantic proximity Read ↗

Derivation and characterization of two human induced pluripotent stem cell lines (NUIGi004-A) and (NUIGi012-A) from two patients with LQT2 disease.Semantic proximity Read ↗

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