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Article

Identification of a nucleotide in 5' untranslated region contributing to virus replication and virulence of Coxsackievirus A16.

Scientific reports - 10 Feb 2016

Li Zhaolong, Liu Xin, Wang Shaohua, Li Jingliang, Hou Min, Liu Guanchen, Zhang Wenyan, Yu Xiao-Fang

Abstract excerpt

Coxsackievirus A16 (CA16) and enterovirus 71 (EV71) are two main causative pathogens of hand, foot and mouth disease (HFMD). Unlike EV71, virulence determinants of CA16, particularly within 5' untranslated region (5'UTR), have not been investigated until now. Here, a series of nucleotides present in 5'UTR of lethal but not in non-lethal CA16 strains were screened by aligning nucleotide sequences of lethal...

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PMID: 26861413
DOI: 10.1038/srep20839
PMCID: PMC4748407

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