Improving antibody thermostability based on statistical analysis of sequence and structural consensus data

Abstract excerpt

Background: The use of Monoclonal Antibodies (MAbs) as therapeutics has been increasing over the past 30 years due to their high specificity and strong affinity toward the target. One of the major challenges toward their use as drugs is their low thermostability, which impacts both efficacy as well as manufacturing and delivery. Methods: To aid the design of thermally more stable mutants, consensus sequence-based...