Article

Sequence-Only Prediction of Antibody Fab Thermostability Using Protein Language Model Embeddings

2026-01-02

Abstract excerpt

Antibody developability is a critical consideration in therapeutic manufacturing, with conformational stability—measured by melting temperature (T m )—being a key determinant of manufacturability. Traditional experimental approaches to assess T m are costly and low-throughput, while statistical models offer limited predictive power and generalizability. In this study, we present a scalable, sequence-only machine...

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Identifiers and source

Literature Corpus work: 8765fdce-9b5e-55ce-8c2d-1cc1e973c32b
DOI: 10.64898/2025.12.30.697053

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