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Cellular Environment and Phenotypic Heterogeneity: How Data-Driven Modeling Finds the Smoking Gun.

International journal of molecular sciences - 10 Jun 2022

Guilbert Marie, Courtade Emmanuel, Thommen Quentin

Abstract excerpt

The cellular environment modifies cellular phenotypes, in particular, the stress response phenotype, which easily exhibits high phenotypic heterogeneity due to the common characteristics of its regulatory networks. The aim of this work is to quantify and interpret the impact of collagen type I, a major component of the cellular environment, on the phenotypic heterogeneity of the cellular response. Our approach...

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PMID: 35742979
DOI: 10.3390/ijms23126536
PMCID: PMC9223694

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