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Article

Exploiting cell-to-cell variability to detect cellular perturbations.

PloS one - 1 Jan 2014

Dey Gautam, Gupta Gagan D, Ramalingam Balaji, Sathe Mugdha, Mayor Satyajit, Thattai Mukund

Abstract excerpt

Any single-cell-resolved measurement generates a population distribution of phenotypes, characterized by a mean, a variance, and a shape. Here we show that changes in the shape of a phenotypic distribution can signal perturbations to cellular processes, providing a way to screen for underlying molecular machinery. We analyzed images of a Drosophila S2R+ cell line perturbed by RNA interference, and tracked 27...

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Identifiers

PMID: 24594940
DOI: 10.1371/journal.pone.0090540
PMCID: PMC3942435

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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