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Article

Cellular Deconstruction: Finding Meaning in Individual Cell Variation.

Trends in cell biology - 1 Oct 2015

Eberwine James, Kim Junhyong

Abstract excerpt

The advent of single cell transcriptome analysis has permitted the discovery of cell-to-cell variation in transcriptome expression of even presumptively identical cells. We hypothesize that this variability reflects a many-to-one relation between transcriptome states and the phenotype of a cell. In this relation, the molecular ratios of the subsets of RNA are determined by the stoichiometric constraints of the...

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PMID: 26410403
DOI: 10.1016/j.tcb.2015.07.004
PMCID: PMC4584424

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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