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Genetically Determined Serum Uric Acid and Alzheimer's Disease Risk.

Journal of Alzheimer's disease : JAD - 1 Jan 2018

Yuan Hongjuan, Yang Wenjie

Abstract excerpt

To evaluate whether genetically increased serum uric acid levels influence the risk of Alzheimer's disease (AD), we used genome-wide significant single nucleotide polymorphisms for uric acid as the instrumental variables, and undertook a Mendelian randomization (MR) study to estimate the effect of uric acid on the risk of AD. The MR method prevents bias due to reverse causation (e.g., uric acid changes because of...

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PMID: 30149453
DOI: 10.3233/JAD-180538

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