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Article

Elevated c-fos expression is correlated with phenotypic switching of human vascular smooth muscle cells derived from lower limb venous varicosities.

Journal of vascular surgery. Venous and lymphatic disorders - 1 Jan 2021

Guo Zhenyu, Luo Chentao, Zhu Ting, Li Li, Zhang Wan

Abstract excerpt

BACKGROUND: Lower limb venous varicosities (VVs) are clinically common; however, their molecular underpinnings are far from well elucidated. Previous studies have demonstrated that the phenotypic transition of vascular smooth muscle cells (VSMCs) plays a critical role in VV pathogenesis and that c-fos is upregulated in VSMCs from VVs. The present study investigated the histologic and cytologic changes in VVs and...

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PMID: 32360331
DOI: 10.1016/j.jvsv.2020.03.019

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