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Article

Alteration of the Nucleotide Excision Repair (NER) Pathway in Soft Tissue Sarcoma.

International journal of molecular sciences - 28 Jul 2022

Pasqui Adriano, Boddi Anna, Campanacci Domenico Andrea, Scoccianti Guido, Bernini Andrea, Grasso Daniela, Gambale Elisabetta, Scolari Federico, Palchetti Ilaria, Palomba Annarita, Fancelli Sara, Caliman Enrico, Antonuzzo Lorenzo, Pillozzi Serena

Abstract excerpt

Clinical responses to anticancer therapies in advanced soft tissue sarcoma (STS) are unluckily restricted to a small subgroup of patients. Much of the inter-individual variability in treatment efficacy is as result of polymorphisms in genes encoding proteins involved in drug pharmacokinetics and pharmacodynamics. The nucleotide excision repair (NER) system is the main defense mechanism for repairing DNA damage...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35955506
DOI: 10.3390/ijms23158360
PMCID: PMC9369086

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