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Article

Genetic polymorphisms in nucleotide excision repair pathway influences response to chemotherapy and overall survival in osteosarcoma.

International journal of clinical and experimental pathology - 1 Jan 2015

Sun Yongjian, Wu Yi, Li Weicheng, Kong Zhen, Zou Xiaoming

Abstract excerpt

We analyzed the role of genetic polymorphisms of six important NER pathway genes in response to chemotherapy and clinical outcome of osteosarcoma patients. A prospective study including 172 osteosarcoma patients was conducted between January 2009 and January 2011. The polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used for ERCC1 rs11615 and rs2298881, ERCC2 rs13181 and...

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Source

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Identifiers

PMID: 26339355
PMCID: PMC4555683

Genes

ERCC1
ERCC2
ERCC4
ERCC5
XPA
XPC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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