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Article

ERCC5/XPG, ERCC1, and BRCA1 gene status and clinical benefit of trabectedin in patients with soft tissue sarcoma.

Cancer - 1 Aug 2011

Italiano Antoine, Laurand Armelle, Laroche Audrey, Casali Paolo, Sanfilippo Roberta, Le Cesne Axel, Judson Ian, Blay Jean-Yves, Ray-Coquard Isabelle, Bui Binh, Coindre Jean-Michel, Nieto Antonio, Tercero Juan-Carlos, Jimeno Jose, Robert Jacques, Pourquier Philippe

Abstract excerpt

BACKGROUND: The objective of this study was to determine whether specific single nucleotide polymorphisms (SNPs) from nucleotide excision repair (NER) and homologous recombination (HR) DNA repair pathways are associated with sensitivity to trabectedin in patients with soft tissue sarcoma (STS). METHODS: The authors analyzed excision repair cross-complementation group 5/xeroderma pigmentosum group G (ERCC5/XPG)...

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Share to Antineoplastic Agents, Alkylating
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 21287534
DOI: 10.1002/cncr.25925

Genes

BRCA1
ERCC1
ERCC5
STS

Provenance

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