Article
Genetic polymorphisms of the XPG and XPD nucleotide excision repair genes in sarcoma patients.
International journal of cancer - 1 Oct 2006
Le Morvan Valérie, Longy Michel, Bonaïti-Pellié Catherine, Bui Binh, Houédé Nadine, Coindre Jean-Michel, Robert Jacques, Pourquier Philippe
Abstract excerpt
There are more than 50 subtypes of soft tissue sarcomas, among which 30% are associated with specific genetic alterations, including translocations. Several studies have reported associations between cancer risk and polymorphisms of DNA repair genes from the nucleotide excision repair (NER) pathway. NER involves more than 20 proteins whose inactivation leads to xeroderma pigmentosum (XP) or cockayne syndrome...
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