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Article

Senotherapeutic-like effect of Silybum marianum flower extract revealed on human skin cells

16 Dec 2021

Abstract excerpt

Cellular senescence causes irreversible growth arrest of cells. Prolonged accumulation of senescent cells in tissues leads to increased detrimental effects due to senescence associated secretory phenotype (SASP). Recent findings suggest that elimination of senescent cells has a beneficial effect on organismal aging and lifespan. In this study, using a validated replicative senescent human dermal fibroblasts...

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PMID: 34914725
DOI: 10.1371/journal.pone.0260545

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