Article
DNA methyltransferase 3 alpha and TET methylcytosine dioxygenase 2 restrain mitochondrial DNA-mediated interferon signaling in macrophages.
Immunity - 9 Aug 2022
Cobo Isidoro, Tanaka Tiffany N, Chandra Mangalhara Kailash, Lana Addison, Yeang Calvin, Han Claudia, Schlachetzki Johannes, Challcombe Jean, Fixsen Bethany R, Sakai Mashito, Li Rick Z, Fields Hannah, Mokry Michal, Tsai Randy G, Bejar Rafael, Prange Koen, de Winther Menno, Shadel Gerald S, Glass Christopher K
Abstract excerpt
Deleterious somatic mutations in DNA methyltransferase 3 alpha (DNMT3A) and TET mehtylcytosine dioxygenase 2 (TET2) are associated with clonal expansion of hematopoietic cells and higher risk of cardiovascular disease (CVD). Here, we investigated roles of DNMT3A and TET2 in normal human monocyte-derived macrophages (MDM), in MDM isolated from individuals with DNMT3A or TET2 mutations, and in macrophages isolated...
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