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Article

Identification of DHODH as a therapeutic target in small cell lung cancer

6 Nov 2019

Abstract excerpt

Small cell lung cancer (SCLC) is an aggressive lung cancer subtype with extremely poor prognosis. No targetable genetic driver events have been identified, and the treatment landscape for this disease has remained nearly unchanged for over 30 years. Here, we have taken a CRISPR-based screening approach to identify genetic vulnerabilities in SCLC that may serve as potential therapeutic targets. We used a...

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PMID: 31694929
DOI: 10.1126/scitranslmed.aaw7852

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