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Programmable DARPin-based receptors for the detection of thrombotic markers

8 Aug 2022

Abstract excerpt

Cellular therapies remain constrained by the limited availability of sensors for disease markers. Here we present an integrated target-to-receptor pipeline for constructing a customizable advanced modular bispecific extracellular receptor (AMBER) that combines our generalized extracellular molecule sensor (GEMS) system with a high-throughput platform for generating designed ankyrin repeat proteins (DARPins). For...

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PMID: 35941237
DOI: 10.1038/s41589-022-01095-3

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