Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

ELIMINATOR: essentiality analysis using multisystem networks and integer programming.

BMC bioinformatics - 6 Aug 2022

Antoranz Asier, Ortiz María, Pey Jon

Abstract excerpt

A gene is considered as essential when it is indispensable for cells to grow and replicate in a certain environment. However, gene essentiality is not a structural property but rather a contextual one, which depends on the specific biological conditions affecting the cell. This circumstantial essentiality of genes is what brings the attention of scientist since we can identify genes essential for cancer cells but...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Clustered Regularly Interspaced Short Palindromic Repeats
Share to Gene Knockout Techniques

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genes, Essential

Share to Mutation

Share to Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 35933325
DOI: 10.1186/s12859-022-04855-z
PMCID: PMC9357337

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

ELIMINATOR: essentiality analysis using multisystem networks and integer programming.PMID 35933325Read ↗

ELIMINATOR: Essentiality anaLysIs using MultIsystem Networks And inTeger prOgRammingSemantic proximity Read ↗

ELIMINATOR: Essentiality anaLysIs using MultIsystem Networks And inTeger prOgRammingSemantic proximity Read ↗

OGEE v3: Online GEne Essentiality database with increased coverage of organisms and human cell lines.Semantic proximity Read ↗

A Co-essentiality Network of Cancer Driver Genes Better Prioritizes Anticancer DrugsSemantic proximity Read ↗

Human gene essentiality.Semantic proximity Read ↗

Contextual diversity of the human cell-essential proteomeSemantic proximity Read ↗

CEN-tools: an integrative platform to identify the contexts of essential genes.Semantic proximity Read ↗

GRETA: an R package for mapping <i>in silico</i> genetic interaction and essentiality networksSemantic proximity Read ↗

GRETTA: an R package for mapping in silico genetic interaction and essentiality networks.Semantic proximity Read ↗

A single-gene-based AI model to identify core and context-specific essential genes by biological interpretation from pooled genome-wide CRISPR and omics dataSemantic proximity Read ↗

Assessing tissue-specific gene expression of essential genes from human and mouseSemantic proximity Read ↗

HELP: A computational framework for labelling and predicting human common and context-specific essential genesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.