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Emergence of immune escape at dominant SARS-CoV-2 killer T cell epitope

14 Jul 2022

Abstract excerpt

We studied the prevalent cytotoxic CD8 T cell response mounted against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Spike glycoprotein 269-277 epitope (sequence YLQPRTFLL) via the most frequent human leukocyte antigen (HLA) class I worldwide, HLA A ∗ 02. The Spike P272L mutation that has arisen in at least 112 different SARS-CoV-2 lineages to date, including in lineages classified as "variants of...

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PMID: 35931021
DOI: 10.1016/j.cell.2022.07.002

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