SARS-CoV-2 spike L452R variant evades cellular immunity and increases infectivity.

doi:10.1016/j.chom.2021.06.006

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SARS-CoV-2 spike L452R variant evades cellular immunity and increases infectivity.

Cell host & microbe - 14 Jul 2021

Motozono Chihiro, Toyoda Mako, Zahradnik Jiri, Saito Akatsuki, Nasser Hesham, Tan Toong Seng, Ngare Isaac, Kimura Izumi, Uriu Keiya, Kosugi Yusuke, Yue Yuan, Shimizu Ryo, Ito Jumpei, Torii Shiho, Yonekawa Akiko, Shimono Nobuyuki, Nagasaki Yoji, Minami Rumi, Toya Takashi, Sekiya Noritaka, Fukuhara Takasuke, Matsuura Yoshiharu, Schreiber Gideon, Ikeda Terumasa, Nakagawa So, Ueno Takamasa, Sato Kei

Abstract excerpt

Many SARS-CoV-2 variants with naturally acquired mutations have emerged. These mutations can affect viral properties such as infectivity and immune resistance. Although the sensitivity of naturally occurring SARS-CoV-2 variants to humoral immunity has been investigated, sensitivity to human leukocyte antigen (HLA)-restricted cellular immunity remains largely unexplored. Here, we demonstrate that two recently...

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Identifiers

PMID: 34171266
DOI: 10.1016/j.chom.2021.06.006
PMCID: PMC8205251

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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