Article
An enhancer variant associated with breast cancer susceptibility in Black women regulates TNFSF10 expression and antitumor immunity in triple-negative breast cancer.
Human molecular genetics - 1 Jan 2023
Han Yoo Jane, Zhang Jing, Hardeman Ashley, Liu Margaret, Karginova Olga, Romero Roger, Khramtsova Galina F, Zheng Yonglan, Huo Dezheng, Olopade Olufunmilayo I
Abstract excerpt
Women of African ancestry have the highest mortality from triple-negative breast cancer (TNBC) of all racial groups. To understand the genomic basis of breast cancer in the populations, we previously conducted genome-wide association studies and identified single nucleotide polymorphisms (SNPs) associated with breast cancer in Black women. In this study, we investigated the functional significance of the top...
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