Article
Genome-wide association studies in women of African ancestry identified 3q26.21 as a novel susceptibility locus for oestrogen receptor negative breast cancer.
Human molecular genetics - 1 Nov 2016
Huo Dezheng, Feng Ye, Haddad Stephen, Zheng Yonglan, Yao Song, Han Yoo-Jeong, Ogundiran Temidayo O, Adebamowo Clement, Ojengbede Oladosu, Falusi Adeyinka G, Zheng Wei, Blot William, Cai Qiuyin, Signorello Lisa, John Esther M, Bernstein Leslie, Hu Jennifer J, Ziegler Regina G, Nyante Sarah, Bandera Elisa V, Ingles Sue A, Press Michael F, Deming Sandra L, Rodriguez-Gil Jorge L, Nathanson Katherine L, Domchek Susan M, Rebbeck Timothy R, Ruiz-Narváez Edward A, Sucheston-Campbell Lara E, Bensen Jeannette T, Simon Michael S, Hennis Anselm, Nemesure Barbara, Leske M Cristina, Ambs Stefan, Chen Lin S, Qian Frank, Gamazon Eric R, Lunetta Kathryn L, Cox Nancy J, Chanock Stephen J, Kolonel Laurence N, Olshan Andrew F, Ambrosone Christine B, Olopade Olufunmilayo I, Palmer Julie R, Haiman Christopher A
Abstract excerpt
Multiple breast cancer loci have been identified in previous genome-wide association studies, but they were mainly conducted in populations of European ancestry. Women of African ancestry are more likely to have young-onset and oestrogen receptor (ER) negative breast cancer for reasons that are unknown and understudied. To identify genetic risk factors for breast cancer in women of African descent, we conducted a...
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