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Article

Lower frequency of TLR9 variant associated with protection from breast cancer among African Americans.

PloS one - 1 Jan 2017

Chandler Madison R, Keene Kimberly S, Tuomela Johanna M, Forero-Torres Andres, Desmond Renee, Vuopala Katri S, Harris Kevin W, Merner Nancy D, Selander Katri S

Abstract excerpt

INTRODUCTION: Toll-like receptor 9 (TLR9) is an innate immune system DNA-receptor that regulates tumor invasion and immunity in vitro. Low tumor TLR9 expression has been associated with poor survival in Caucasian patients with triple negative breast cancer (TNBC). African American (AA) patients with TNBC have worse prognosis than Caucasians but whether this is due to differences in tumor biology remains...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 28886076
DOI: 10.1371/journal.pone.0183832
PMCID: PMC5590816

Genes

TLR9
MAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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