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Article

Altered muscle oxidative phenotype impairs exercise tolerance but does not improve after exercise training in multiple sclerosis.

Journal of cachexia, sarcopenia and muscle - 1 Oct 2022

Spaas Jan, Goulding Richie P, Keytsman Charly, Fonteyn Lena, van Horssen Jack, Jaspers Richard T, Eijnde Bert O, Wüst Rob C I

Abstract excerpt

BACKGROUND: Patients with multiple sclerosis (MS) experience reduced exercise tolerance that substantially reduces quality of life. The mechanisms underpinning exercise intolerance in MS are not fully clear. This study aimed to determine the contributions of the cardiopulmonary system and peripheral muscle in MS-induced exercise intolerance before and after exercise training. METHODS: Twenty-three patients with...

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Source

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Identifiers

PMID: 35929063
DOI: 10.1002/jcsm.13050
PMCID: PMC9530506

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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